Author/Editor		Goto, M; Yoshioka, T; Ravindranath, T; Battelino, T; Young, RI; Zeller, WP
Title		LPS injected into the pregnant rat late in gestation does not induce fetal endotoxemia
Type		članek
Source		Res Commun Mol Pathol Pharmacol
Vol. and No.		Letnik 85, št. 1
Publication year		1994
Volume		str. 109-12
Language		eng
Abstract		End toxin is abortifacient. Abortion may be due to maternal, fetal or combined endotoxemia. The present study was performed to evaluate if fetal rat endotoxemia was induced by maternal endotoxemia in late gestation. An intraperitoneal injection of smooth lipopolysaccharide (Escherichia coli LPA nad Shigella flexneri LPS) or rough LPS (Rc mutant Escherichia coli LPS) induced Limulus activity in maternal plasma, but not fetal plasma. These results suggest that fetal rat endotoxemia is not induced during maternal endotoxemia. Thus, the abortion may not be due to fetal endotoxemia.
Descriptors		ENDOTOXINS FETAL DISEASES LIPOPOLYSACCHARIDES PREGNANCY TOXEMIAS RATS ANIMALS, LABORATORY ESCHERICHIA COLI FETAL BLOOD GESTATIONAL AGE LIMULUS TEST SHIGELLA FLEXNERI