| Author/Editor | Treiber, Milena; Gorenjak, Maksimiljan; Pečovnik-Balon, Breda | |
| Title | Serum cystatin-C as a marker of acute kidney injury in the newborn after perinatal hypoxia/asphyxia | |
| Type | članek | |
| Vol. and No. | Letnik 18, št. 1 | |
| Publication year | 2014 | |
| Volume | str. 57-67 | |
| ISSN | 1744-9979 - Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy | |
| Language | eng | |
| Abstract | We evaluated cystatin-C (cysC) in the umbilical blood as a predictor of acute kidney injury (AKI) after perinatal hypoxia/asphyxia compared with creatinine (Cr). One hundred full-term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). CysC and Cr were measured in blood samples from the umbilical cord at birth (cysC-umb and Cr-umb) and from a peripheral vein 3 days later (cysC-3 and Cr-3). At birth, the mean level of cysC in healthy term babies was found to be 1.39 +/- 0.19 mg/L and 1.34 +/- 0.21 mg/L after 3 days of life, not significantly decreased (P=0.137). The mean of cysC in the AS group was 2.12 +/- 0.53 mg/L in cord blood and 1.56 +/- 0.32 g/L in day 3 blood samples, also decreased (P<0.001) and different from the control (P<0.001). Cr levels, determined simultaneously at birth were different (P=0.001) between the control (62.74 +/- 12.84 micro mol/L) and AS (72.60 +/- 15.55 micro mol/L) group, significantly decreased after 3 days in both groups (P<0.001). The receiver-operating characteristic curve analysis, comparing AS and the control group, showed area under the curve for cysC-umb, cysC-3, Cr-umb and Cr-3 (0.918; 0.698; 0.692; 0.660). The highest diagnostic accuracy was achieved with a chosen cut-off for cysC-umb of 1.67 mg/L (sensitivity of 84.0%, specificity of 90.0%) or 1.69 mg/L (sensitivity of 82.0%, specificity of 94.0%). Our results indicate serum CysC is a more sensitive marker of glomerular filtration rate than Cr in the newborns. | |
| Keywords | akutna ledvična poškodba asfiksija hipoksija kreatinin cistatin C novorojenček glomerulna filtracija, ocena |