Author/Editor		Petrovič, Danijel; Peterlin, Borut
Title		GSTM1-null and GSTT1-null genotypes are associated with essential arterial hypertension in patients with type 2 diabetes
Type		članek
Vol. and No.		, št. 1
Publication year		2014
ISSN		0009-9120 - Clinical biochemistry
Language		eng
Abstract		Objective To evaluate whether the genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1), Ile105Val of the GSTP1 (rs947894), and the Val16Ala polymorphism of the MnSOD (rs4880) are associated with essential arterial hypertension (EAH) in Caucasians with type 2 diabetes. Design and methods 1015 Slovenian subjects (Caucasians) with type 2 diabetes with/without EAH were enrolled in the cross-sectional study. Genotypes were determined by multiplex PCR amplification and PCR-restriction fragment length polymorphism method. Results In the cross-sectional study, GSTM1-null genotype and GSTT1-null genotype were associated with EAH in subjects with type 2 diabetes (59.0% vs. 50.3%, p = 0.007; 28.5% vs. 20.7%, p = 0.008; consequently). Conclusion After adjustment for age, body mass index, and hsCRP level, GSTM1-null and GSTT1-null genotypes were found to be independent risk factors for the development of EAH in Slovenian patients with type 2 diabetes.
Keywords		oxidative stress genes gene polymorphism oksidativni stres geni genski polimorfizem