Author/Editor		Vizjak, A
Title		Glomerulni in zunajglomerulni imunski depoziti pri sistemskem lupusu eritematozusu
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1994
Volume		str. 134
Language		slo
Abstract		The author investigated the characteristics of extraglomerular immune desposits in different organs as well as their association with glomerular deposits, histomorphological changes in particular organs, serum antinuclear antibodies, and for deposits in uninvolved skin also their association with clinical affection of other parts of the skin. The study was mainly retrospective including 269 patients with systemic lupus erythematosus (SLE). Biopsy and authopsy tissue samples were examined by immunofluorescence, light microscopy, selected cases also by electron microscopy. Granular deposits of immune reactants were observed in glomeruli in 99 percent, choroid plexus in 82 percent, skin 75 percent, spleen 73 percent, heart 71 percent, extraglomerular kidney vessels 62 percent, tubuli and interstitium 57 percent, salivary glands 57 percent, brain 56 percent, lung 49 percent, liver 42 percent, skeletal muscle 36 percent. In few cases deposits were also observed in joint synovia, peripheral nerves, lymph nodes, gut, pancreas, liver, thyroid, observed in joint synovia, peripheral nerves, lymph nodes, gut, pancreas, liver, thyroid, parathyroids, suprarenal gland, pituitary, uterus, ovary, and breast. In all organs, except the skin, deposits were most frequently expressed in blood vessels, mainly arterioles and small arteries, and rarely in venules and veins. They were also noted along epithelial besement membranes in different organs, sarcolemas in sceletal and heart muscle, free in the interstitium in all organs, along arrector pili muscle in the skin, and along the smooth muscle bundles in lung and gut. Immune deposits along epithelial basement membranes and sarcolemas were associated with vascular deposits in all organs, except on the dermal-epidermal junction, where they were frequently not accompanied by vascular deposition.(trunc.)
Descriptors		LUPUS ERYTHEMATOSUS, SYSTEMIC ANTIGEN-ANTIBODY COMPLEX AUTOANTIBODIES MICROSCOPY, ELECTRON IMMUNOHISTOCHEMISTRY BIOPSY AUTOPSY KIDNEY SKIN MUSCLES HEART LUNG BRAIN