Author/Editor		Šarc, Lucija; Jamšek, Marija; Grenc, Damjan; Brvar, Miran
Title		Smernice za zdravljenje zastrupitev s paracetamolom
Translated title		Guidelines for paracetamol poisoning treatment
Type		članek
Vol. and No.		Letnik 83, št. 3
Publication year		2014
Volume		str. 201-208
ISSN		1581-0224 - Zdravniški vestnik
Language		slv
Abstract		Paracetamol overdose results in an accumulation of the reactive, hepatotoxic metabolite N-acetyl-p-benzoquinoneimin (NAPKQI) which can cause serious liver injury. Recognition of paracetamol overdose, hepatotoxicity risk estimation and early treatment are crutial in paracetamol poisoniong management. In ingestion of potential hepatotoxic dose of paracetamol decontamination and early treatment with N-acetylcysteine (NAC) are indicated. Both, 20-hours intravenous and 72-hurs oral regimes of NAC administration are successful. By antidote regime selection we should consider patient condition and time after paracetamol overdose. In severe hepatotoxicity, criteria for liver transplantation should be regularly evaluated and mechanisms for liver transplantation must be activated in time.
Keywords		paracetamol poisoning liver injury paracetamol zastrupitev jetrna odpoved