Author/Editor		Gerdan, Lavinia; Šegedin, Barbara; Veninga, Theo; Schild, Steven E.; Rades, Dirk
Title		Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer
Type		članek
Vol. and No.		Letnik 33, št. 9
Publication year		2013
Volume		str. 3887-3889
ISSN		0250-7005 - Anticancer research
Language		eng
Abstract		BACKGROUND/AIM: To investigate the prognostic role of the number of involved extracranial organs in patients with brain metastasis from small-cell lung cancer (SCLC). PATIENTS AND METHODS: Data of 155 patients receiving whole-brain radiotherapy (WBRT) alone for brain metastasis from SCLC were retrospectively evaluated. In addition to the number of involved extracranial organs, six potential prognostic factors were analyzed including WBRT regimen, age, gender, Karnofsky performance score (KPS), number of brain metastases, and interval from diagnosis of SCLC to WBRT. RESULTS: Six-month survival rates of patients with involvement of 0, 1, 2, and %3 extracranial organs were 52%, 29%, 9%, and 0%, respectively (p<0.001). On multivariate analysis, the number of involved extracranial organs remained significant (p=0.003). Older age (p=0.005), lower KPS (p<0.001), and greater number of brain metastases (p=0.005) were also significantly associated with poorer survival. CONCLUSION: The number of involved extracranial organs is an independent prognostic factor of survival in SCLC patients with brain metastasis.
Keywords		rak glave možganske metastaze ekstrakranialni organi preživetje brain metastasis SCLC extracranial organs survival