Author/Editor		Lukan, Anja; Černilec, Maja; Vranac, Tanja; Popović, Mara; Čurin-Šerbec, Vladka
Title		Regional distribution of anchorless prion protein, PrP226*, in the human brain
Type		članek
Publication year		2014
ISSN		1933-6896 - Prion
Language		eng
Abstract		It was shown previously that truncated molecules of prion protein can be found in brains of patients with some types of transmissible spongiform encephalopathy. One such molecule, PrP226*, is a fragment of prion protein, truncated at Tyr226. It was found to be present in aggregates, from which it can be released using chaotropic salts. In this study we investigated the distribution of PrP226* in Creutzfeldt-Jakob disease affected human brain, employing the mAb V5B2, specifically recognizing this fragment. The results show that PrP226* is not evenly distributed among different regions of human brain. Among brain regions analyzed, the fragment was found most likely to be accumulated in the cerebellum. Its distribution correlates with the distribution of PrPSc.
Keywords		prion protein human brain Creutzfeldt-Jakob disease prionski protein človeški možgani Creutzfeldt-Jakobova bolezen