Author/Editor | Kores-Plesničar, Blanka | |
Title | Efficacy and tolerability of agomelatine in the treatment of depression | |
Type | članek | |
Vol. and No. | Letnik 8 | |
Publication year | 2014 | |
Volume | str. 603-612 | |
ISSN | 1177-889X - Patient preference and adherence | |
Language | eng | |
Abstract | Depression is a severe and usually recurrent mental disorder which often leads to a significant impairment of everyday functioning, a reduced quality of life, and also great suffering of the patients. The treatment of a depressive disorder is not only limited to acute treatment; it also requires prolonged management. Patient compliance is of utmost importance. Unpleasant adverse effects and their impact on everyday living often lead to a premature discontinuation of antidepressant treatment and result in an unfavorable treatment outcome. The new antidepressant agomelatine, a melatonergic MT1/MT2 agonist and 5-HT2C receptor antagonist, has exhibited good antidepressant efficacy in acute, short-term, and long-term treatment. The adverse effect profile of agomelatine has been proven to be favorable and comparable to placebo, which is very important for good treatment compliance and adherence. | |
Keywords | agomelatine cicardian rhythms depression agomelatin cikadni ritem depresija |