Author/Editor		Montanič, Sendi; Rajčević, Uroš; Čurin-Šerbec, Vladka
Title		Novel immuno - and stem cell-based therapies
Type		članek
Source		In: The partners and the objectives of Trans2Care, an Italy-Slovenia cross-border network of science and healthcare institutions Trieste : Università degli Studi, Dipartimento di Scienza della Vita
Publication year		2014
Volume		str. 93-97
Language		eng
Abstract		The main areas of the research at the Blood Transfusion Center of Slovenia are cell therapies, stem cells and new diagnostic reagents, based on monoclonal antibodies (mAbs). Our laboratories are equipped for cell-culture work (certified GLP; GMP in reconstruction), molecular biology, immunological techniques and biochemistry. In the course of our research we conducted studies and applied projects (the last mainly industrial) beside production of reagents, with common topic - the antibodies. They were prepared and used to optimise and validate ELISA tests for quality control assessment of the end-product (polyclonal antibodies, in production of drugs), to study protein structure, for immunodiagnostics and as potential immunotherapeutics. Among different mAbs, which we produced in the last decade, a panel of mAbs against prion protein (PrP) and mAbs against bilitranslocase (prepared in collaboration with the University of Trieste) will be studied with different project partners in the scope of Trans2Care. We are fully dedicated to translate the results of the basic research onto applied, possibly clinical level and to contribute to improved healthcare in a sense of advanced modes of immunotherapeutics development and cell based therapies.
Keywords		human prion protein bilitranslocase monoclonal antibodies človeški prionski protein bilitranslokaza monoklonska protitelesa