Author/Editor		Stegnar, Mojca; Peternel, Polona; Keber, Dušan; Vene, Nina
Title		Poor fibrinolytic response to venous occlusion by different criteria in patients with deep vein thrombosis
Type		članek
Source		Thromb Res
Vol. and No.		Letnik 64, št. 4
Publication year		1991
Volume		str. 445-53
Language		eng
Abstract		Five criteria for poor response to a 20 min venous occlusion test were applied to 58 patients 3 months or more after acute deep vein thrombosis (DVT). The criteria were arbitrarily defined as the last 5 percentiles of response distributions in an age- and sex-matched healthy control group of 51 subjects. The criteria were: 1. euglobulin clot lysis time after venous occlusion greater than or equal to 140 min; 2. t-PA activity after venous occlusion less than or equal to 0.04 IU/ml; 3. increase in t-PA antigen above resting value less than or equal to 2-fold; 4. ratio between t-PA antigen increase and resting PAI activity less than or equal to 0.5 ng/IU; 5. PAI activity after venous occlusion greater than or equal to 6 IU/ml. The last criterion of poor response was the only one that was significantly more frequently reached by patients than by controls: 28 percent (p less than 0.005) of all DVT patients and 35 percent (p less than 0.005) of the subgroup with idiopathic DVT (N = 34) were found to be poor responders. The percentage of poor responders according to the other four criteria was 7-11 percent in all patients and 9-15 percent in the subgroup with idiopathic DVT and thus was not significantly higher than in controls (5 percent by definition). It was concluded that residual PAI activity after venous occlusion might be a useful criterion for prospective studies on recurrence of DVT.
Descriptors		FIBRINOLYSIS THROMBOPHLEBITIS ADOLESCENCE ADULT ALTEPLASE BLOOD GLUCOSE BODY MASS INDEX CONSTRICTION MIDDLE AGE PLASMINOGEN INACTIVATORS RECURRENCE RISK FACTORS THROMBOPHLEBITIS