Author/Editor     Breznik, R; Borko, E
Title     Effectiveness of antiestrogens in infertile men
Type     članek
Source     Arch Androl
Vol. and No.     Letnik 31, št. 1
Publication year     1993
Volume     str. 43-8
Language     eng
Abstract     Eighty-nine oligozoospermic men, treated by clomiphene or tamoxifen or with no treatment at all, were evaluated during a 4-year follow-up period. Ejaculate volume, sperm concentration, and sperm motility were determined and concentrations of prolactin (PRL), estradiol, beta hCG, prostaglandin E2, zinc, and fructose were ascertained. Isoenzyme LDH-C4 activity and serum PRL and follicle stimulating hormone were also determined. During treatment there was only a minimum increase in sperm concentration. No improvement in sperm motility and no alteration in ejaculate volume were observed. The pregnancy rate was lower in the partners of patients receiving treatment (23.8 percent) than in the partners of those receiving none (29.6 percent). Statistically the difference is insignificant. After antiestrogen therapy, prolactin concentrations in serum decreased and zinc concentrations in seminal plasma increased. For the treatment of idiopathic oligozoospermia in infertile men, clomiphene and tamoxifen were ineffective medication.
Descriptors     CLOMIPHENE
OLIGOSPERMIA
TAMOXIFEN
FOLLOW-UP STUDIES
PREGNANCY
SEMEN
SPERMATOZOA