| Author/Editor | Čurin-Šerbec, V; Novak, D; Babnik, J; Turk, D; Gubenšek, F | |
| Title | Immunological studies of the toxic site in ammodytoxin A | |
| Type | članek | |
| Source | FEBS Lett | |
| Vol. and No. | Letnik 280, št. 1 | |
| Publication year | 1991 | |
| Volume | str. 175-8 | |
| Language | eng | |
| Abstract | Two monoclonal antibodies against the native ammodytoxin A and four site-directed polyclonal antibodies against synthetic peptides derived from the primary structure of the toxin were prepared in order to estimate the localization of its toxic site. Some of the antibodies neutralized the lethal toxicity of the toxin, thus indicating an approximate position of the toxic or receptor binding site on the molecule that is different from those predicted by comparison with a number of known sequences. | |
| Descriptors | VIPER VENOMS PHOSPHOLIPASES A AMINO ACID SEQUENCE ANTIBODIES, MONOCLONAL ANTIGENS BINDING SITES CYTOTOXICITY TESTS, IMMUNOLOGIC MICE MICE, INBRED BALB C MOLECULAR SEQUENCE DATA PHOSPHOLIPASES A PROTEIN CONFORMATION STEREOISOMERS VIPER VENOMS |