Author/Editor		Kandus, A; Benedik, M; Bren, AF; Drinovec, J; Fliser, D; Knap, B; Kladnik, S; Ivanovich, P
Title		Inhibition of complement activation with EDTA in vivo during sham hemodialysis
Type		članek
Source		Int J Artif Organs
Vol. and No.		Letnik 14, št. 8
Publication year		1991
Volume		str. 515-7
Language		eng
Abstract		To check whether in vivo EDTA prevents complement activation resulting from blood contact with the dialyzer membrane, sham hemodialysis (HD) was performed in seven healthy volunteers using Cuprophan hollow-fiber dialyzers. Blood samples were drawn from the arterial and venous blood lines of the dialyzer before and after EDTA was infused into the arterial line. Venous line plasma C3a concentrations before EDTA infusion were significantly higher than after EDTA. Also, venous line plasma C3a concentrations before and after EDTA infusion were significantly higher than in the arterial line. These results indicate that complement activation can be attenuated by EDTA during sham HD. Technical improvements in the procedure may permit complete inhibition of complement activation.
Descriptors		COMPLEMENT ACTIVATION COMPLEMENT 3A EDETIC ACID HEMODIALYSIS ADULT CELLULOSE KIDNEY, ARTIFICIAL MEMBRANES, ARTIFICIAL