Author/Editor		Mendenhall, William M.; Mancuso, Anthony A.; Strojan, Primož; Beitler, Jonathan J.; Suárez, Carlos; Lee, Tsair-Fwu; Langendijk, Johannes A.; Corry, June; Eisbruch, Avraham; Rinaldo, Alessandra; Ferlito, Alfio
Title		Impact of primary tumor volume on local control after definitive radiotherapy for head and neck cancer
Type		članek
Vol. and No.		Letnik 36, št. 9
Publication year		2014
Volume		str. 1363-1367
ISSN		1097-0347 - Head & neck
Language		eng
Abstract		Background: The impact of primary tumor volume (pTV) on local control after definitive radiotherapy (RT) for head-and-neck squamous cell carcinomas (SCCs) is unclear. Methods: Pertinent literature was reviewed to address the impact of pTV on local control after definitive RT for head-and-neck SCCs. Results: Reproducibility of pTV calculations is probably influenced by inter-observer variability and may be reduced by relying on experienced observers. The impact of pTV on local control after definitive RT is probably influenced by primary site. A relatively limited impact of pTV on local control after RT for oropharyngeal SCCs might be attributable to human papilloma virus positivity. Conclusions: pTV may be a useful parameter to select patients for treatment with definitive RT, particularly for those with laryngeal SCCs. Patients with high-volume primary cancers where the probability of local control with a functional larynx is low are likely better treated with surgery.
Keywords		rak glave in vratu ploščatocelični rak radioterapija head and neck cancer radiotherapy carcinoma