Author/Editor		Šeruga, Boštjan; Zadnik, Vesna; Grašič-Kuhar, Cvetka; Marinko, Tanja; Čufer, Tanja; Zakotnik, Branko; Zorman, Darko; Ocaña, Alberto; Amir, Eitan
Title		Association of aromatase inhibitors with coronary heart disease in women with early breast cancer
Type		članek
Vol. and No.		Letnik 32, št. 4
Publication year		2014
Volume		str. 99-104
ISSN		0735-7907 - Cancer investigation
Language		eng
Abstract		As compared to tamoxifen aromatase inhibitors (AIs) may increase the risk of heart disease. Here we explored the association between the use of AIs and coronary artery disease (CAD) in a population-based observational study. In a small and heterogeneous population of 74 women with early breast cancer who received adjuvant hormonal therapy and subsequently underwent cardiac angiography, AIs significantly increased the hazard for CAD (HR 3.23, 95% confidence intervals [CI] 1.26-8.25, p = .01) compared to tamoxifen. Our results suggest that therapy with AIs may increase the risk for CAD.
Keywords		rak dojke zaviralci inhibitorji koronarne bolezni aromatase inhibitor coronary artery disease angiography