Author/Editor		Milutinović, S; Gašparovič, V; Milutinović, E; Buturović-Ponikvar, J
Title		Ticlopidine improves dialysis clearance of solutes in uremic patients by reducing blood clotting in dialyser fibers
Type		članek
Source		Int J Artif Organs
Vol. and No.		Letnik 16, št. 5
Publication year		1993
Volume		str. 249-52
Language		eng
Abstract		Ticlopidine, a platelet aggregation inhibitor was tested, in a double blind comparative cross-over study versus placebo, in 51 dialysed uremic patients who had increased dialyser blood clotting ( more th. 25 fibers clotted/dialyser). At the end of a 7-day treatment period with 250 mg daily, the clearance of urea, creatinine and phosphate was determined at 30 and 210 minutes of dialysis, as well as the number of fibers clotted at the end of dialysis. Ticlopidine improved dialyser clearances for urea, creatinine and phosphate from 165 +/- 41 to 182 +/- 35 (p less th. 0.01), 135 +/- 37 to 143 +/- 35 (p less th. 0.05), and 120 +/- 36 to 130 +/- 35 (p less th. 0.05) ml/min, respectively, at 30 min of HD and a similar effect was seen after 210 min of dialysis. The number of dialyser fibers clotted after dialysis was reduced by ticlopidine therapy from 110 +/- 48 to 15 +/- 8 (p less th. 0.01). Ticlopidine reduced the initial dialysis-induced drop in leucocyte count by 20 percent (p less th. 0.05); no change in platelet or erythrocyte count was observed. Two out of 51 patients experienced an adverse reaction from ticlopidine (cutaneous haematoma and minor gingival bleeding). We conclude that ticlopidine is an efficient and safe drug for dialysed uremic patients since it can reduce blood clotting and thereby increase dialysis efficiency.
Descriptors		BLOOD COAGULATION HEMODIALYSIS TICLOPIDINE ADOLESCENCE ADULT AGED BLOOD CELL COUNT CREATININE DOUBLE-BLIND METHOD MIDDLE AGE PHOSPHATES TICLOPIDINE UREA UREMIA