| Author/Editor | Locatelli, Igor | |
| Title | Časovni potek resnih neželenih učinkov verapamila | |
| Translated title | Time course of serious adverse effects of verapamil | |
| Type | članek | |
| Vol. and No. | Letnik 64, št. 1 | |
| Publication year | 2013 | |
| Volume | str. 33-38 | |
| ISSN | 0014-8229 - Farmacevtski vestnik | |
| Language | slv | |
| Abstract | Resni neželeni učinki zdravil na srčno-žilnem sistemu so pogost vzrok za hospitalizacijo. V ZDA je verapamil izmed teh zdravil povezan z največ smrtnimi primeri. Resni neželeni učinki verapamila se kažejo kot znatno znižankrvni tlak, bradikardija, AV blok višje stopnje in srčno popuščanje ter so odvisni od plazemskih koncentracij verapamila. Farmakokinetične lastnosti verapamila zaznamujejo obsežen predsistemski metabolizem, nelinearna farmakokinetika in stereoselektivni metabolizem. Čas pojava resnih neželenih učinkov po aplikaciji verapamila je odvisen od farmacevtke oblike verapamila. Pri zastrupitvah z verapamilom je čas trajanja resnih neželenih učinkov precej podaljšan in lahko traja več dni.Serious adverse effects of cardiovascular drugs are common cause of hospitalization. In the USA verapamil poisoning is associated with the most deaths among the cardiovascular drugs. Serious adverse effects of verapamil are shown as substantial decrease in blood pressure, bradycardia, serious AV block, and heart failure. These effects are related to verapamil plasma concentrations. Pharmacokinetic properties of verapamil involve extensive presystemic metabolism, nonlinear pharmacokinetics, and stereoselective metabolism. The onset time of serious adverse effects depends on verapamil formulation. In case of verapamil intoxication the duration of serious adverse effects can be considerably extended and persist for several days. | |
| Keywords | zdravila farmakokinetika farmakodinamika verapamil neželeni učinki |