| Author/Editor | Vasle, Anže; Landekar, Nina; Mrhar, Aleš | |
| Title | Analiza uporabnosti podatkovne baze Lexicomp za prepoznavanje potencialnih interakcij med zdravili | |
| Translated title | Analysis of usefulness of database Lexicomp for detecting potential drug-drug interactions | |
| Type | članek | |
| Vol. and No. | Letnik 65, št. 3 | |
| Publication year | 2014 | |
| Volume | str. 240-246 | |
| ISSN | 0014-8229 - Farmacevtski vestnik | |
| Language | slv | |
| Abstract | Farmacevti se pri svojem delu vedno pogosteje soočajo s pojavom polifarmakoterapije. Pri obvladovanju težav, povezanih z zdravili, uporabljajo elektronske podatkovne baze, ki med drugim uporabnika opozorijo na pojav potencialnih interakcij med zdravili. Namen tega prispevka je ovrednotiti bazo Lexicomp s stališča ustreznosti podatkov v opisih interakcij. V raziskavo smo vključili paciente Klinike za infekcijske bolezni in vročinska stanja Univerzitetnega kliničnega centra Ljubljana, pri katerih smo ugotovili potencialne interakcije. Od 25 opisov interakcij pri 7 bolnikih smo jih 7 označili kot ustrezne, 11 kot neustrezne, 5 kot neopredeljene, 2 pa ni bilo mogoče analizirati. Rezultati raziskave kažejo, daje pri izvajanju farmakoterapijskih pregledov s pomočjo podatkovnih baz sicer smiselno pridobiti podatke o potencialnih interakcijah, jih je pa potrebno kritično ovrednotiti pred končno odločitvijo o intervenciji.Pharmacists are more and more often faced with the problem of polypharmacotherapy. In order to manage drug related problems they use electronic databases that, among other things, alert the healthcare provider of potential drug-drug interactions. Our aim was to validate Lexi-Comp database from the viewpoint of adequacy of interaction descriptions in the database. Our research included patients from the Clinic for Infectious Diseases and Febrile Illnesses at the University Medical Centre Ljubljana with discovered potential interactions. Of total 25 interaction descriptions in 7 patients there were 7 classified as 'appropriate', 11 as 'inappropriate' and 5 as 'undefined', while 2 interactions could not be examined with LexiComp. Results clearly imply that electronic databases are quite an useful tool for detecting potencial drug-drug interactions, however, a thorough evaluation of clinical status of individual patient is required before intervention or final decision is carried out. | |
| Keywords | interakcije med zdravili podatkovna baza Lexicomp ustreznost zapisov zanesljivost virov uporabnost v klinični praksi drug-drug interactions Lexicomp database adequacy of descriptions reliability of literature sources applicability in clinical practice |