Author/Editor		Jafri, RA; Britton, KE; Nimmon, CC; Solanki, K; Al-Nahhas, A; Bomanji, J; Fettich, J; Hawkins, LA
Title		Technetium-99m MAG3, a comparison with iodine-123 and iodine-131 orthoiodohippurate, in patients with renal disorders
Type		članek
Source		J Nucl Med
Vol. and No.		Letnik 29, št. 2
Publication year		1988
Volume		str. 147-58
Language		eng
Abstract		A Phase I study in 12 patients with renal disorders compared the simultaneous clearances of 99mTc-labeled mercaptoacetyltriglycine (MAG3) and 131I-labeled orthoiodohippurate (OIH). The ratio of MAG3 to OIH clearance was 0.61 +/- 0.08 as a result of its smaller volume of distribution, ratio 0.65 +/- 0.09, for the clearance half-lives were similar, ratio 1.09 +/- 0.12. A Phase II study performed serially in 20 patients with equal doses of Š99mTcĆMAG3 and Š123IĆOIH gave images of equal quality. The relative renal functions were highly correlated (r = 0.97, p less than 0.001) and transit time analyses gave good correlations: parenchymal transit time index r = 0.81, p less than 0.05. We conclude that Š99mTcĆMAG3 has some advantages over Š99mTcĆDTPA and is a suitable replacement for Š123IĆhippuran in routine renal imaging, relative function, and transit time studies, but not for the accurate estimation of the renal plasma flow.
Descriptors		IODOHIPPURIC ACID KIDNEY DISEASES OLIGOPEPTIDES ORGANOMETALLIC COMPOUNDS RADIOISOTOPE RENOGRAPHY TECHNETIUM ADULT AGED IODOHIPPURIC ACID KIDNEY DISEASES MIDDLE AGE OLIGOPEPTIDES ORGANOMETALLIC COMPOUNDS TECHNETIUM