Author/Editor		Szebeni, Janos; Wahl, SMharon; Popovic, Mikulas; Wahl, L Marry; Gartner, Suzanne; Fine, Robert L; Skalerič, Uroš; Friedmann, Robert M; Weinstein, John N
Title		Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages
Type		članek
Source		Proc Natl Acad Sci U S A
Vol. and No.		Letnik 86, št. 10
Publication year		1989
Volume		str. 3842-6
Language		eng
Abstract		Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory effects of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine against human immunodeficiency virus type 1 (HIV-1) in human monocyte-macrophages. At the same concentrations, DPM does not potentiate the toxic effects of AZT on these cells or on human bone marrow (granulocyte-monocyte) progenitor cells. Since monocyte-macrophage lineage cells appear to be the major reservoir for HIV-1 in vivo, these findings suggest the possibility of using DPM or its analogues in combination chemotherapy of HIV infections.
Descriptors		ANTIVIRAL AGENTS DIPYRIDAMOLE HIV VIRUS REPLICATION ZIDOVUDINE BIOLOGICAL TRANSPORT BONE MARROW CELL SURVIVAL DIDEOXYNUCLEOSIDES DRUG SYNERGISM HIV INTERFERON TYPE I MACROPHAGES MONOCYTES