Author/Editor     Tang, WC; Weil, MH; Sun, S; Noč, M; Gazmuri, RJ; Bisera, J
Title     Gastric intramural PCO2 as monitor of perfusion failure during hemorrhagic and anaphylactic shock
Type     članek
Source     J Appl Physiol
Vol. and No.     Letnik 76, št. 2
Publication year     1994
Volume     str. 572-7
Language     eng
Abstract     Indirect measurement of gastric intramural pH (pHG) utilizing a luminal tonometer in the stomach has been proposed for monitoring the severity and progression of perfusion failure. In the present study, we investigated gastric PCO2 and pHG as indicators and quantitators of the severity of perfusion failure in the experimental rodent model of both hemorrhagic and anaphylactic shock. Gastric intramural PCO2 (PGCO2) and pHG were directly measured with miniaturized sensors inserted into the anterior wall of the stomach. In hemorrhagic shock, animals were bled into a reservoir maintained at a pressure of 35 mmHg. pHG decreased from 7.39 +/- 0.08 to 6.67 +/- 0.11 (P less th. 0.01), and PGCO2 increased from 53 +/- 4 to 136 +/- 3 Torr (P less th. 0.01). Anaphylactic shock was induced in animals that had been sensitized 21 days before with crystallized ovalbumin. Antigen challenge produced an immediate reduction in mean aortic pressure from 144 to 60 mmHg. pHG decreased from 7.40 +/- 0.05 to 6.99 +/- 0.07 (P less th. 0.01), and PGCO2 increased from 48 +/- 5 to 133 +/- 9 Torr (P less th. 0.01). The increases in PGCO2 were highly correlated with decreases in gastric blood flow in both hemorrhagic (r = 0.96) and anaphylactic shock (r = 0.92). The correlations with pHG were more moderate. These experiments demonstrated prominent increases in PGCO2 and H+ during both hemorrhagic and anaphylactic shock. We further noted that the estimation of pHG based on the assumption that HCO3-concentrations of the stomach wall and arterial blood are the same was not fully sustained.
Descriptors     ANAPHYLAXIS
CARBON DIOXIDE
SHOCK, HEMORRHAGIC
STOMACH
BICARBONATES
BLOOD PRESSURE
HYDROGEN-ION CONCENTRATION
PARTIAL PRESSURE
RATS
RATS, SPRAGUE-DAWLEY
REGIONAL BLOOD FLOW