| Author/Editor | Roblek, Tina; Trobec, Katja; Mrhar, Aleš; Lainščak, Mitja | |
| Title | Potential drug-drug interactions in hospitalized patients with chronic heart failure and chronic obstructive pulmonary disease | |
| Type | članek | |
| Vol. and No. | Letnik 10, št. 5 | |
| Publication year | 2014 | |
| Volume | str. 920-932 | |
| ISSN | 1734-1922 - Archives of medical science : AMS | |
| Language | eng | |
| Abstract | Introduction: Polypharmacy is common in patients with chronic heart failure (HF) and/or chronic obstructive pulmonary disease (COPD), but little is known about the prevalence and significance of drug-drug interactions (DDIs). This study evaluates DDIs in hospitalized patients. Material and methods: We retrospectively screened medical charts over a 6-month period for diagnosis of chronic HF and/or COPD. Potential DDIs were evaluated using Lexi-Interact software. Results: Seven hundred and seventy-eight patients were included in the study (median age 75 years, 61% men). The median number of drugs on admission and discharge was 6 (interquartile range (IQR) 4-9) and 7 (IQR 5-), respectively (p = 0.10). We recorded 6.5 +-5.7 potential DDIs per patient on admission and 7.2 +-5.6 on discharge (p = 0.2). From admission to discharge, type-C and type-X potential DDIs increased (p < 0.05 for both). Type X interactions were rare (< 1%), with the combination of a ß-blocker and a ß2 agonist being the most common (64%). There were significantly more type-C and type-D potential DDIs in patients with chronic HF as compared to patients with COPD (p < 0.001). Patients with concomitant chronic HF and COPD had more type-C and type-X potential DDIs when compared to those with individual disease (p < 0.005). An aldosterone antagonist and ACE inhibitor/ ARB were prescribed to 3% of chronic HF patients with estimated glomerular filtration rate < 30 ml/(min x 1.73 m2). Conclusions: The DDIs are common in patients with chronic HF and/or COPD, but only a few appear to be of clinical significance. The increase in potential DDIs from admission to discharge may reflect better guideline implementation rather than poor clinical practice. | |
| Keywords | potential drug-drug interactions chronic heart failure chronic obstructive pulmonary disease statistical analysis |