| Author/Editor | Nikolajević-Starčević, Jovana; Popovič, Dražen; Šantl-Letonja, Marija; Makuc, Jana; Šeruga, Maja; Cokan, Andreja; Jenko Pražnikar, Zala; Stare, Janez; Petrovič, Danijel | |
| Title | Polymorphism Avall of the LDL receptor (rs5925) is associated with carotid-intima media thickness in patients with diabetes mellitus type 2 | |
| Translated title | Polimorfizem Avall receptorja za holesterol LDL (rs5925) je povezan z debelino intime medije pri bolnikih s sladkorno boleznijo tipa 2 | |
| Type | članek | |
| Vol. and No. | Letnik 83, št. Supl. | |
| Publication year | 2014 | |
| Volume | str. I-5-I-12 | |
| ISSN | 1581-0224 - Zdravniški vestnik | |
| Language | eng | |
| Abstract | Increased serum level of lowdensity lipoprotein (LDL) cholesterol is a well established risk factor for atherosclerosis development and progression. Genetic variation in the LDL, receptor gene could modulate serum LDL, level and response to statin treatment thus affecting atherosclerosis development and progression. The present study was designed to investigate the association between polymorphism Avall (rs5952) of the LDL receptor gene with serum lipid levels and carotid intima-media thickness (CIMT) in patients with diabetes mellitus tyoe 2 (DM2).Povečana serumska koncentracija lipoproteinov nizke gostote (LDL) je pomemben dejavnik tveganja za pojav in napredovanje aterosleroze. Genetska variabilnost v genu za receptor LDL lahko vpliva na serumsko koncentracija LDL in odgovor na zdravljenje s statini ter tako na pojav in napredovanje ateroskleroze. V raziskavi smo želeli ugotoviti, ali obstaja povezanost med polimorfizmom Avall gena za receptor LDL (rs5925) s serumskimi ravnmi lipidov in debelino intime medije pri bolnikih s sladkorno boleznijo tipa 2(SB2), | |
| Keywords | diabetes mellitus type 2 atherosclerosis carotid intima-media thickness LDL receptor polymorphism pharmacogenetic sladkorna bolezen tip 2 ateroskleroza LDL receptor polimorfizem debelina intima medije farmakognetika |