Author/Editor		Rovensky, J; Kovalančik, M; Raunova, L; Bošmansky, K; Blažičkova, S; Buc, M; Mališ, F
Title		Cell-mediated immunity in primary gout
Type		članek
Source		New Eur Rheumatol
Vol. and No.		Letnik 1, št. 2
Publication year		1993
Volume		str. 4-7
Language		eng
Abstract		The number of T-lymphocytes (active and total) revealed significant individual differences in 36 percent of the cases during acute gouty attack. Statistically significant differences were found in the number of theophylline-sensitive T-lymphocytes at the time of acute gouty attack, 7 days post attack, and in the intercritical stage, in comparison with the control group of healthy persons. The number of theophyllineresistent T-lymphocytes was significantly increased only at the time of acute gouty attack and 7 days post attack. In the intercritical stage of gout, the number of theophyllineresistent T-lymphocytes did not differ from the control group. After stimulation of lymphocytes with mitogens (PHA and ConA), we found a statistically significantly increased response in arthritis urica patients. The results of testing the lymphocyte subpopulations in peripheral blood using monoclonal antibodies showed an increase in the relative number of CD4 lymphocytes induced by the increased number of helper inducers (CD4+/C4SRA-). Our results demonstrate that in the acute and intercritical stages of primary gout T-lymphocytes are involved in the immunopathogenetic mechanisms, probably via lymphokine release by urate stimulation.
Descriptors		GOUT IMMUNITY, CELLULAR T-LYMPHOCYTES ROSETTE FORMATION LYMPHOKINES ADULT MIDDLE AGE AGED CD4 LYMPHOCYTE COUNT LYMPHOCYTE TRANSFORMATION ANTIBODIES, MONOCLONAL