Author/Editor		Strojan, Primož; Grašič-Kuhar, Cvetka; Žumer, Barbara; Kadivec, Maksimiljan; Karner, Katarina Barbara; Fajdiga, Igor; Jančar, Boris; Gale, Nina; Poljak, Mario; Kocjan, Boštjan; Zakotnik, Branko
Title		TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck
Type		članek
Vol. and No.		Letnik 36, št. 11
Publication year		2014
Volume		str. 1555-1561
ISSN		1097-0347 - Head & neck
Language		eng
Abstract		Background: To assess efficacy and toxicity of TPF induction chemotherapy and concomitant immunochemoradiotherapy with cetuximab and cisplatin in unresectable head and neck carcinoma. Methods: Treatment consisted of TPF induction chemotherapy (docetaxel 75 mg/m2 day 2; cisplatin, 75 mg/m2 day 2; and 5-fluorouracil 750 mg/m2 days 1-4; 4 cycles), followed by radiotherapy and concomitant weekly cetuximab, (250 mg/m2, after a loading dose of 400 mg/m2) and cisplatin (30 mg/m2).Results: 25/30 patients completed four cycles of induction chemotherapy. Six or more concomitant infusions of cisplatin and cetuximab were administered in 13/25 and 18/25 patients, respectively. The 2-year locoregional control, disease-free survival and overall survival were 47%, 47%, and 50%, respectively. Patients with grade 2 skin reaction to cetuximab had a superior outcome. Conclusion: The tested regimen was effective; however, cetuximab and low-dose cisplatin after induction TPF increased the treatment toxicity. A grade 2 skin rash correlated with improved efficacy.
Keywords		rak glave in vratu radioterapija ploščatocelični rak TPF indukcijska kemoterapija konkomitantno obsevanje neresektabilni rak head and neck cancer radiotherapy induction TPF chemotherapy