Author/Editor		Iles, Mark M.; Hočevar, Marko; Novaković, Srdjan
Title		The effect on melanoma risk of genes previously associated with telomere length
Type		članek
Vol. and No.		Letnik 106, št. 10
Publication year		2014
ISSN		0027-8874 - Journal of the National Cancer Institute
Language		eng
Abstract		Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
Keywords		melanomi geni genotipi genetika telomere length melanoma genotype genes