Author/Editor		Petrič, Rok; Gazić, Barbara; Bešić, Nikola
Title		Prognostic factors for disease-specific survival in 108 patients with Hürthle cell thyroid carcinoma
Type		članek
Publication year		2014
ISSN		1471-2407 - BMC cancer
Language		eng
Abstract		Background: Hürthle cell thyroid carcinoma (HCTC) is a rare disease. It is believed that it is more aggressive than follicular thyroid carcinoma. The aim of our study was to identify factors associated with disease-specific and disease-free survival. Methods: Altogether, 108 patients with HCTC (26 male, 82 female; median age 62 years; range 19%87 years) treated at our Institute from 1972 to 2011 were included in the present retrospective study. Data on age, clinical and histopathological factors, tumor stage, recurrence, disease-free and disease-specific survival were collected. Univariate analysis was used to identify factors associated with disease-specific survival. Cox%s multivariate regression model was used to identify independent prognostic factors for disease-specific survival. Results: The follow-up period was 1 to 337 (median 105) months. Of 108 patients, 12 (11%) had distant and 8 (7%) had locoregional metastases before primary treatment. Recurrence was diagnosed in 26 cases (24%): locoregional, distant, and both locoregional and distant in 12, 11, and 3 cases, respectively. The 5-year, 10-year, and 20-year disease-specific survival were 96%, 88%, and 67%, respectively. Independent prognostic factors for disease-specific survival were: age of patients at diagnosis, distant metastases and residual tumor after surgery. Conclusion: Long disease-specific survival was found in patients with HCTC younger than 45 years of age without distant metastases and without residual tumor after surgery.
Keywords		rak ščitnice Hürtlejeve celice Hürtlejev tumor kirurgija Hürthle cell thyroid carcinoma surgery pathology