Author/Editor		Stegnar, M; Pentek, M
Title		Age-related changes in the basal level of tissue-type plasminogen activator and plasminogen activator inhibitor 1
Type		članek
Source		Fibrinolysis
Vol. and No.		Letnik 6, št. 3
Publication year		1992
Volume		str. 55-7
Language		eng
Abstract		Tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were determined in resting plasma of 91 healthy women and 100 healthy men, 19 to 80 years old. It was observed that t-PA antigen steadily increased with age, being at 71-80 years (9.3 ng/ml) about three fold higher than at 19-30 years (3.8 ng/ml, p less th. 0.001). In all decades of their lifetime women had on average 27 percent lower t-PA antigen than men. PAI-1 antigen also increased with age (p less th. 0.002): the peak value was observed in the age group 51-60 years (58 percent increase compared to 19-30 years). No significant age-related changes in t-PA and PAI activity were observed. In multiple regression analysis t-PA antigen was independently related to age, while PAI-1 antigen only retained a significant association with plasma insulin.
Descriptors		ALTEPLASE PLASMINOGEN ACTIVATOR INHIBITOR 1 AGE FACTORS ADULT MIDDLE AGE AGED