Author/Editor     Winder, Michael; Tobin, Gunnar; Zupančič, Daša; Romih, Rok
Title     Signalling molecules in the urothelium
Type     članek
Vol. and No.     Letnik 2014
Publication year     2014
ISSN     2314-6141 - BioMed research international
Language     eng
Abstract     The urothelium was long considered to be a silent barrier protecting the body from the toxic effects of urine. However, today a number of dynamic abilities of the urothelium are well recognized, including its ability to act as a sensor of the intravesical environment. During recent years several pathways of these urothelial abilities have been proposed and a major part of these pathways includes release of signalling molecules. It is now evident that the urothelium represents only one part of the sensory web. Urinary bladder signalling is finely tuned machinery of signalling molecules, acting in autocrine and paracrine manner, and their receptors are specifically distributed among different types of cells in the urinary bladder. In the present review the current knowledge of the formation, release, and signalling effects of urothelial acetylcholine, ATP, adenosine, and nitric oxide in health and disease is discussed.
Keywords     urothelium
signalling molecules
urinary bladder
urotelij
signalne molekule
sečni mehur