Author/Editor     Harambat, Jérôme; Battelino, Nina
Title     Adult height in patients with advanced CKD requiring renal replacement therapy during childhood
Type     članek
Vol. and No.     Letnik 9, št. 1
Publication year     2014
Volume     str. 92-99
ISSN     1555-905X - Clinical journal of the American Society of Nephrology : CJASN
Language     eng
Abstract     Background and objectives Growth and final height are of major concern in children with ESRD. This study sought to describe the distribution of adult height of patients who started renal replacement therapy (RRT) during childhood and to identify determinants of final height in a large cohort of RRT children. Design, setting, participants, & measurements A total of 1612 patients from 20 European countries who started RRT before 19 years of age and reached final height between 1990 and 2011 were included. Linear regression analyses were performed to calculate adjusted mean final height SD score (SDS) and to investigate its potential determinants. Results The median final height SDS was 1.65 (median of 168 cm in boys and 155 cm in girls). Fifty-five percent of patients attained an adult height within the normal range. Adjusted for age at start of RRT and primary renal diseases, final height increased significantly over time from 2.06 SDS in children who reached adulthood in 19901995 to 1.33 SDS among those reaching adulthood in 20062011. Older age at start of RRT, more recent period of start of RRT, cumulative percentage time on a functioning graft, and greater height SDS at initiation of RRT were independently associated with a higher final height SDS. Patients with congenital anomalies of the kidney and urinary tract and metabolic disorders had a lower final height than those with other primary renal diseases. Conclusions Although final height remains suboptimal in children with ESRD, it has consistently improved over time.
Keywords     Growth
final height
children
ESRD