Author/Editor		Budihna, NV; Milčinski, M; Skralovnik-Štern, A; Peternel, A
Title		Measurement of right ventricular ejection fraction with first pass technique at injecting 99mTc-MAA in lung perfusion scintigraphy
Type		članek
Source		In: Hoefer R, Bergmann H, Sinzinger H, eds. Radioactive isotopes in clinical medicine and research. 20th international symposium, Badgastein 1992. Stuttgart: Schattauer,
Publication year		1993
Volume		str. 318-21
Language		eng
Abstract		Forty patients, 18-85 years old, were investigated for clinically suspected pulmonary embolism (PE). Ventilation scintigraphicaly with 133Xe was performed first, in four standard projections. Right ventricular ejection fraction (RVEF) was obtained in RAO projection during the transit of 99mTc-MAA applied as a slow bolus flushed with 20 ccm of normal saline. 15-20 frames per second were performed. The endsystolic and enddiastolic regions of interest were used for calculating RVEF on Digital PDP 11/34 or Macintosh IIfx computers. Lung perfusion scintigraphy was accomplished afterwards in the same projections as ventilation scintigraphy. Lung scans were analysed for probability of lung embolism according to PIOPED criteria. In the group with low probability of PE (16pts) RVEF was 61+-9 percent. In the group with indeterminate probability of PE (8pts) RVEF was 54+-9 prcent. The group of 16pts with high probability of PE had RVEF 47+-13 percent (mean+-SD), what was lower than in normals (p less th. 0.001). Significant negative correlation between the number of V/Q mismatched segmental or large subsegmental defects and RVEF was found (r=-0.6, p less th. 0.001), what was not the case in the group with nonsegmental defects. It is concluded that useful additional data about the right ventricular function can be obtained with the single injection of MAA in conjunction with lung perfusino scintigraphy. Significant negative correlation was found between the extent of PE and RVEF.
Descriptors		VENTRICULAR FUNCTION, LEFT PULMONARY EMBOLISM RADIONUCLIDE VENTRICULOGRAPHY