| Author/Editor | Mut, Fernando; Giubbini, Raffaele; Vitola, Joao; Lusa, Lara; Šobić-Šaranović, D.P.; Peix, Amalia; Bertagna, Francesco; Bui, Dieu Hang; Cunha, Carlos; Obaldo, Jerry | |
| Title | Detection of post-exercise stunning by early gated SPECT myocardial perfusion imaging | |
| Type | članek | |
| Vol. and No. | Letnik 21, št. 6 | |
| Publication year | 2014 | |
| Volume | str. 1168-1176 | |
| ISSN | 1071-3581 - Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology | |
| Language | eng | |
| Abstract | Background Transient post-ischemic LV dysfunction due to myocardial stunning in patients with coronary artery disease can be missed by conventional gated SPECT (GSPECT) acquisitions. The aim of this IAEA-sponsored multi-center study was to determine whether early post-exercise imaging is more likely to detect stunning than conventional without adversely affecting image quality or perfusion information. Methods and Results Patients undergoing exercise/rest GSPECT were enrolled in this international multicenter study. Post-exercise studies were acquired at 15 +- 5 minutes after radiotracer injection (Stress-1) and repeated at 60 +- 15 minutes (Stress-2). Rest studies (R) were acquired at 60 minutes post injection. A core laboratory quantitatively assessed perfusion pattern and LV blinded to the acquisition time. Ischemia was defined as summed stress score (SDS) >-4, and stunning was defined as the difference between rest and post-stress LVEF (delta-LVEF). In the 229 patients enrolled into the study, both image quality and perfusion information were similar between Stress-1 and Stress-2. Post-stress LVEF was associated with both ischemia and time of acquisition, with a significant correlation between SDS and delta-LVEF, which was stronger at Stress-1 than Stress-2 in the ischemic compared to the non-ischemic population (r = 0.23 vs 0.08, P = 0.10). Conclusions Early post-exercise imaging is feasible, and can potentially improve the detection of post-ischemic stunning without compromising image quality and perfusion data. | |
| Keywords | left ventricular function ischemic myocardial dysfunction stress testing funkcija levega prekata ishemična miokardni disfunkcija testiranje izjemnih situacij |