Author/Editor		Koder, Silvo; Repnik, Katja; Ferkolj, Ivan; Pernat Drobež, Cvetka; Skok, Pavel; Weersma, Rinse K.; Potočnik, Uroš
Title		Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients
Type		članek
Vol. and No.		Letnik 16, št. 3
Publication year		2015
Volume		str. 191-204
ISSN		1462-2416 - Pharmacogenomics
Language		eng
Abstract		Aim: To see if SNPs could help predict response to biological therapy using adalimumab (ADA) in Crohn's disease (CD). Materials & methods: IBDQ index and CRP levels were used to monitor therapy response. We genotyped 31 CD-associated genes in 102 Slovenian CD patients. Results: The strongest association for treatment response defined as decrease in CRP levels was found for ATG16L1 SNP rs10210302. Additional SNPs in 7 out of 31 tested CD-associated genes (PTGER4, CASP9, IL27, C11orf30, CCNY, IL13, NR1I2) showed suggestive association with ADA response. Conclusion: Our results suggest ADA response in CD patients is genetically predisposed by SNPs in CD risk genes and suggest ATG16L1 as most promising candidate gene for drug response in ADA treatment.
Descriptors		Crohn Disease genetics
Keywords		adalimumab biological drugs pharmacogenomics single nucleotide polymorphism