Author/Editor		Bratkovič, Tomaž; Preželj, Andrej
Title		Zdravljenje bakterijskih okužb z bakteriofagi
Translated title		Bacteriophage therapy
Type		članek
Vol. and No.		Letnik 59, št. 3
Publication year		2008
Volume		str. 129-134
ISSN		0014-8229 - Farmacevtski vestnik
Language		slv
Abstract		Ideja o uporabi bakteriofagov za zdravljenje okužb, povzročenih z bakterijskimi patogeni, je stara že skoraj stoletje. Nerazumevanje biologije bakteriofagov in pomanjkanje nadzorovanih kliničnih raziskav, predvsem pa odkritje antibiotikov, so bakteriofagno terapijo po začetnem zagonu v zahodnih državah pahnile v pozabo. Vse bolj pereč problem odpornosti bakterijskih patogenov proti klinično pomembnim antibiotikom je v zadnjem desetletju obudil zanimanje za bakteriofagna zdravila. Znanje, ki je rezultat sodobnih raziskav, ponuja realno možnost novih terapevtskih pristopov in odpira tudi nekatera povsem nova področja uporabe bakteriofagov.The use of bacteriophage for combating bacterial infections was proposed almost a century ago. However, after the initial enthusiasm the idea quickly faded in the West with the discovery of antibiotics, accompanied by lack of phage biology understanding and insufficient proof of therapeutic efficacy of bacteriophage medicines due to inappropriately designed clinical trials. Today, as we are faced with accelerating emergence of bacterial resistance to antibiotics, the idea of bacteriophage-based drugs was brought back to life. Knowledge gathered over all these years offers a solid foundation on which to build new therapeutic approaches and develop alternative areas of bacteriophage application.
Keywords		bakterijske okužbe bakteriofagi antibiotiki encibiotiki