| Author/Editor | Novak, Polona; Bogataj, Marija; Mrhar, Aleš | |
| Title | Alginat v dostavnih sistemih s prirejenim sproščanjem | |
| Translated title | Alginate in controlled drug delivery systems | |
| Type | članek | |
| Vol. and No. | Letnik 58, št. 6 | |
| Publication year | 2008 | |
| Volume | str. 293-301 | |
| ISSN | 0014-8229 - Farmacevtski vestnik | |
| Language | slv | |
| Abstract | Probiotiki so živi mikroorganizmi, ki po zaućitju ugodno vplivajo na zdravje. Kadar je gostiteljeva fiziologija prizadeta zaradi porušenega ravnotežja črevesne mikrobiote, je zelo dobrodošla zunanja probiotična podpora. Učinkovitost probiotikov je odraz njihovega delovanja po različnih medsebojno prepletenih mehanizmih in tako opravljajo veliko koristnih nalog. Predvsem zmanjšajo pogostnost okužb, prek metabolnih procesov uravnajo fiziologijo organizma ter okrepijo gostiteljev imunski sistem. Tržno dostopni probiotični izdelki so namenjeni samozdravljenju in so neomejeno dostopni uporabnikom. Zato morajo biti varni, imeti majhno tveganje za neželene učinke ter ne smejo biti niti genotoksioeni niti kancerogeni. Proizvajalci teh izdelkov morajo zagotoviti izbiro probiotikov, izdelanih po natančno določenih selekcijskih merilih varnostne, funkcionalne in tehnološke kakovosti. Samo probiotiki, ki izpolnjujejo te kriterije, zmorejo preživeti neugodne pogoje v prebavilih in se naseliti v okolju debelega črevesa, kjer lahko izrazijo svoj probiotični učinek.Controlled drug delivery systems frequently offer significant benefit in comparison with immediate release dosage forms from the efficiency and safety viewpoint. Controlled release can be achieved using various polymers. Alginateis naturally occurring polysaccharide extracted from kelp. It is linear polymer, composed of homopolymeric D-mannuronic and L-guluronic acid blocks and heteropolymeric blocks where the monomers alternate. An important property is the formation of two types of gel, i.e. an acid gel in acidic medium and ionotropic gel in the presence of multivalent cations. Due to its ability to gel and swell and some other properties, alginate is very suitable for the design of controlled release drug delivery systems. Furthermore, the preparation of alginate matrix under mild conditions enables also the incorporation of cells and biomolecules like proteins, enzymes and DNA with retention of full biological activity. By the selection of an appropriate type of alginate and structure and composition of drug delivery system time and/or region controlled delivery can be achieved. | |
| Keywords | alginat ogrodni sistem ionotropno geliranje prirejeno sproščanje ciljana dostava |