Author/Editor		Kikelj, Danijel
Title		Učinkovine za zmanjševanje čezmerne telesne mase in zdravljenje debelosti
Translated title		Drugs for treatment of overweight and obesity
Type		članek
Vol. and No.		Letnik 61, št. 2
Publication year		2010
Volume		str. 101-105
ISSN		0014-8229 - Farmacevtski vestnik
Language		slv
Abstract		Učinkovine za zmanjševanje čezmerne telesne mase in zdravljenje debelosti sozelo maloštevilne, zato imajo velik pomen raziskave novih učinkovitejših in varnejših tovrstnih učinkovin. Potencialne strategije za iskanje novih učinkovin proti debelosti obsegajo zmanjševanje dovajanja energije telesu z manjšim vnosom hrane preko stimulacije anoreksigenih signalov in blokiranjem oreksigenih signalov ter stimulacija porabe energije. V tem pregledu podajamo pregled aktualnih in nedavno ukinjenih učinkovin za zdravljenje debelosti in novih možnih terapevtskih pristopov.Currently available drug therapy of overweight and obesity is very limited, therefore development of more effective drugs has become an important goal. The two general strategies to achieve weight loss are reduction of energy intake by stimulation of anorexigenic signals or inhibition of orexigenic signals, and increase of energy expenditure. This review focuses on approved and recently removed anti-obesity drugs, as well as on new approaches for drug treatment of obesity.
Keywords		debelost zdravljenje debelosti orlistat sibutramin rimonabant fentermin