| Author/Editor | Trdan Lušin, Tina; Trontelj, Jurij | |
| Title | In vitro modeli za preučevanje metabolizma učinkovin v jetrih | |
| Translated title | In vitro models for investigation of drug metabolism in the liver | |
| Type | članek | |
| Vol. and No. | Letnik 62, št. 4 | |
| Publication year | 2011 | |
| Volume | str. 171-174 | |
| ISSN | 0014-8229 - Farmacevtski vestnik | |
| Language | slv | |
| Abstract | V prispevku so sistematično predstavljeni eksperimentalni modeli za preučevanje jetrnega metabolizma učinkovin in vitro. Opisani so naslednji modeli po rastoči stopnji kompleksnosti: rekombinantni encimi, mikrosomi, citosol, S9 frakcija, izolirani hepatociti, celične linije, jetrne rezine in perfundirana jetra. Predstavljene so njihove prednosti, slabosti in omejitve ter področja uporabe.This article gives a systematic review of in vitro experimental models for hepatic drug metabolism. The presented models include: recombinant enzymes, microsomes, cytosol, S9 fraction, isolated hepatocytes, cell lines, liver tissue slices and perfused liver. For each model, a comprehensive overview is given, including application, benefits, and drawbacks. | |
| Keywords | metabolizem zdravilne učinkovine eksperimentalni modeli in vitro modeli subcelične frakcije |