| Author/Editor | Nyboe, Anders Andersen; Devroey, Paul; Arce, Joan-Carles; Vlaisavljević, Veljko; Gavrić-Lovrec, Vida; Reljič, Milan; Kovač, Vilma; Kovačič, Borut; Muršič, Jasna; Kristovič, Marija; Hanžel, Daniela; Knuplež, Suzana; Čižek-Sajko, Mojca; Križančić Bombek, Lidija; Herceg, Naca; Piperski, Marija; Hojnik, Nina; Gorenjak, Maksimiljan | |
| Title | Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial | |
| Type | članek | |
| Vol. and No. | Letnik 21, št. 12 | |
| Publication year | 2006 | |
| Volume | str. 3217-3227 | |
| ISSN | 0268-1161 - Human reproduction (Oxford, England) | |
| Language | eng | |
| Abstract | Background: LH activity may influence treatment response and outcome in IVF cycles. Methods: A randomized, assessor-blind, multinational trial compared ongoing pregnancy rates (primary end-point) in 731 women undergoing IVF after stimulation with highly purified menotrophin (HP-hMG) (n = 363) or recombinant FSH (rFSH) (n = 368) following a long GnRH agonist protocol. Patients received identical pre- and post-randomization interventions. One or two embryos were transferred on day 3. Results: More oocytes were retrieved (P< 0.001) after rFSH treatment (11.8) compared with HP-hMG treatment (10.0), but a higher proportion developed into top-quality embryos (P = 0.044) with HP-hMG (11.3%) than with rFSH (9.0%). At the end of stimulation, lower estradiol (E(2)) (P = 0.031) and higher progesterone (P < 0.001) levels were found with rFSH, even after adjusting for follicular response. The distribution of hypo-, iso- and hyper-echogenic endometrium showed a significant (P = 0.023) shift towards the hyperechogenic pattern after rFSH treatment. The ongoing pregnancy rate per cycle was 27% with HP-hMG and 22% with rFSH [odds ratio (95% confidence interval): 1.25 (0.89-1.75)]. Conclusion: Superiority of HP-hMG over rFSH in ongoing pregnancy rate could not be concluded from this study, but non-inferiority was established. Pharmacodynamic differences in follicular development, oocyte/embryo quality, endocrine response and endometrial echogenicity exist between HP-hMG and rFSH preparations, which may be relevant for treatment outcome. | |
| Descriptors | Infertility, Female Neplodnost, ženska Fertilization in Vitro Oploditev in vitro Follicle Stimulating Hormone Folikel stimulirajoči hormon Embryo Transfer Zarodek, prenos Menotropins Menotropini Recombinant Proteins Rekombinantni proteini Oocyte Donation Oocit, dajalka Pregnancy Outcome Nosečnost, izid therapy Zdravljenje therapeutic use Terapevtska raba therapeutic use Terapevtska raba therapeutic use Terapevtska raba |