Author/Editor		Berezin, Alexander; Zulli, Anthony; Kerrigan, Steve; Petrovič, Danijel; Kruzliak, Peter
Title		Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases
Type		članek
Publication year		2015
ISSN		0009-9120 - Clinical biochemistry
Language		eng
Abstract		Endothelial-derived microparticles (EMPs) are a novel biological marker of endothelium injury and vasomotion disorders that are involved in pathogenesis of cardiovascular, metabolic, and inammatory diseases. Circulating levels of EMPs are thought to reect a balance between cell stimulation, proliferation, apoptosis, and cell death. Increased EMPs may be de!ned in several cardiovascular diseases, such as stable and unstable coronary artery disease, acute and chronic heart failure, hypertension, arrhythmias, thromboembolism, asymptomatic atherosclerosis as well as renal failure, metabolic disorders (including type two diabetes mellitus, abdominal obesity, metabolic syndrome, insulin resistance) and dyslipidemia. This review highlights the controversial opinions regarding impact of circulating EMPs in major cardiovascular and metabolic diseases and summarizes the perspective implementation of the EMPs in risk strati!cation models.
Keywords		cardiovascular diseases metabolic diseases endothelial-derived microparticles endotelno pridobljeni mikrodelci bolezni srca in ožilja presnovne bolezni