Author/Editor		Hudler, Petra; Videtič Paska, Alja; Komel, Radovan
Title		Contemporary proteomic strategies for clinical epigenetic research and potential impact for the clinic
Type		članek
Vol. and No.		Letnik 12, št. 2
Publication year		2015
Volume		str. 197-212
ISSN		1744-8387 - Expert review of proteomics
Language		eng
Abstract		Novel proteomic methods are revealing the intricacy of the epigenetic landscape affecting gene regulation and improving our knowledge of the pathogenesis of complex diseases. Despite the enormous amount of data regarding epigenetic modifications present in DNA and histones, deciphering their biological relevance in the context of the disease and health is currently still an ongoing process. Here, we consider the relationship between epigenetic research in tumorigenesis and the prospect of knowledge transfer to clinical use, focusing primarily on the epigenetic histone post-translational modifications, which could be used as biomarkers. We additionally focus on the use of proteomic techniques in research and evaluate their usefulness in clinical setting.
Keywords		DNA methylation cancer diagnostics metilacija DNK rak diagnostika