Author/Editor		Kariž, Stojan; Mankoč Ramuš, Sara; Petrovič, Danijel
Title		Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus
Type		članek
Publication year		2015
ISSN		0168-8227 - Diabetes research and clinical practice
Language		eng
Abstract		Objectives: The aim of our study was to investigate the relationship between genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and myocardial infarction (MI) in subjects with type 2 diabetes mellitus (T2DM) of Slovenian origin. Methods: The study population consisted of 972 Caucasian subjects with T2DM of more than 10 years' duration: 161 patients with MI and 811 patients with no history of coronary artery disease. Polymorphisms in thioredoxin reductase 2 (TXNRD2) gene, rs1548357, rs4485648, and rs5748469, were studied. Results: Individuals carrying CC + CT genotypes of rs1548357 TXNRD2 polymorphism had lower prevalence of MI compared with TT genotype group (41.6% vs 52.8%, OR=0.589, 95% CI=0.368%0.942, P = 0.027). Conclusions: The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for MI in subjects with T2DM of Slovenian origin.
Keywords		oxidative stress genetic polymorphisms type 2 diabetes mellitus oksidativni stres genetski polimorfizmi diabetes mellitus tipa 2