Author/Editor		Žigon, Polona; Perdan-Pirkmajer, Katja; Tomšič, Matija; Kveder, Tanja; Božič, Borut; Sodin-Šemrl, Snežna; Čučnik, Saša; Ambrožič, Aleš
Title		Anti-phosphatidylserine/prothrombin antibodies are associated with adverse pregnancy outcomes
Type		članek
Vol. and No.		Letnik 2015
Publication year		2015
Language		eng
Abstract		Objective. To determine the prevalence and clinical association of anti-phosphatidylserine/prothrombin antibodies (aPS/PT) in patients with a history of pregnancy complications relevant to antiphospholipid syndrome (APS). Materials and Methods. Two hundred and eleven patients with a history of (a) three or more consecutive miscarriages before 10th week of gestation (WG) (n = 64), (b) death of a morphologically normal fetus beyond 10thWG (n = 72), (c) premature birth of a morphologically normal neonate before 34th WG due to eclampsia, preeclamsia and placental insufficiency (n = 33), and (d) less than three unexplained consecutive miscarriages before 10th WG (n = 42). Subjects sera were analyzed for lupus anticoagulant (LA), anti-cardiolipin (aCL), anti-beta2-glycoprotein I (anti-beta2GPI), and aPS/PT antibodies. Results. 41/169 (24.3%) of patients were positive for at least one measured aPL. The highest prevalence was found for aPS/PT and aCL (13.0% and 12.4%, resp.) followed by LA (7.7%) and anti-beta2GPI (7.1%). 11/169 with APS-related obstetric manifestations had only aPS/PT. 17.8% of patients were positive for LA or aCL and/or anti-beta2GPI; however when adding the aPS/PT results, an additional 7% of patients could be evaluated for APS. Conclusion. aPS/PT are associated with recurrent early or late abortions and with premature delivery irrespective of other aPL.
Keywords		pregnancy complications preeclamsia antiphospholipid syndrome zapleti v nosečnosti preeklampsija antifosfolipidni sindrom