Author/Editor		Vardjan, Nina; Verkhratsky, Alexei; Zorec, Robert
Title		Pathologic potential of astrocytic vesicle traffic
Type		članek
Vol. and No.		Letnik 24, št. 4
Publication year		2015
Volume		str. 599-612
ISSN		0963-6897 - Cell transplantation
Language		eng
Abstract		Vesicles are small intracellular organelles that are fundamental for constitutive housekeeping of the plasmalemma, intercellular transport, and cell-to-cell communications. In astroglial cells, traffic of vesicles is associated with cell morphology, which determines the signaling potential and metabolic support for neighboring cells, includ - ing when these cells are considered to be used for cell transplantations or for regulating neurogenesis. Moreover, vesicles are used in astrocytes for the release of vesicle-laden chemical messengers. Here we review the properties of membrane-bound vesicles that store gliotransmitters, endolysosomes that are involved in the traffic of plasma membrane receptors, and membrane transporters. These vesicles are all linked to pathological states, including amyotrophic lateral sclerosis, multiple sclerosis, neuroinflammation, trauma, edema, and states in which astro - cytes contribute to developmental disorders. In multiple sclerosis, for example, fingolimod, a recently introduced drug, apparently affects vesicle traffic and gliotransmitter release from astrocytes, indicating that this process may well be used as a new pathophysiologic target for the development of new therapies.
Keywords		astrocytes morphology neurogenesis astrociti morfologija nevrogeneza