Author/Editor		Liu, Zhuo; Song, Dan; Yan, Enzhi; Verkhratsky, Alexei; Peng, Liang
Title		Chronic treatment with anti-bipolar drugs suppresses glutamate release from astroglial cultures
Type		članek
Vol. and No.		Letnik 47, št. 5
Publication year		2015
Volume		str. 1045-1051
ISSN		1438-2199 - Amino acids
Language		eng
Abstract		Astroglial cells are fundamental elements of most neurological diseases, including bipolar disorders in which astrocytes show morphological and functional deficiency. Here we report the suppression of astroglial glutamate release by chronic treatment with three anti-bipolar drugs, lithium salt (Li(+)), carbamazepine (CBZ) and valproic acid (VPA). Release of glutamate was triggered by transient exposure of astrocytes to ATP (which activated purinoceptors) and 45 mM K(+) (which depolarised cell membrane to ~-30 mV). In both types of stimulation glutamate release was regulated by Ca(2+) entry through plasmalemmal channels and by Ca(2+) release from the endoplasmic reticulum (ER) intracellular stores. Exposure of astroglial cultures to Li(+), CBZ and VPA for 2 weeks led to a significant (more than 2 times) inhibition of glutamate release, which may alleviate the hyperactivity of the glutamatergic transmission in the brain of patients with bipolar disorders and thus contribute the underlying mechanism of drug action.
Keywords		neuropsychiatric diseases mood disorders valproic acid nevropsihiatrične bolezni motnje razpoloženja valprojska kislina