Author/Editor     Heneka, Michael T; Carson, Monica J; Khoury, Joseph El; Brosseron, Frederic; Feinstein, Douglas L; Jacobs, Andreas H; Wyss-Coray, Tony; Vitorica, Javier; Ransohoff, Richard M; Verkhratsky, Alexei
Title     Neuroinflammation in Alzheimer's disease
Type     članek
Vol. and No.     Letnik 14, št. 4
Publication year     2015
Volume     str. 388-405
ISSN     1474-4422 - Lancet neurology
Language     eng
Abstract     Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of infl ammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the infl ammatory reaction. External factors, including systemic infl ammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease.
Keywords     Alzheimer's disease
brain
immunological mechanisms
Alzheimerjeva bolezen
možgani
imunski mehanizmi