Author/Editor		Zeidán-Chuliá, Fares; Salmina, Alla B.; Malinovskaya, Natalia A.; Noda, Mami; Verkhratsky, Alexei; Fonseca Moreira, José Cláudio
Title		The glial perspective of autism spectrum disorders
Type		članek
Vol. and No.		Letnik 38
Publication year		2014
Volume		str. 160-172
ISSN		0149-7634 - Neuroscience and biobehavioral reviews
Language		eng
Abstract		The aetiology of autism spectrum disorders remains unclear although a growing number of associated genetic abnormalities and environmental factors have been discovered in recent decades. These advancements coincided with a remarkable increase in the comprehension of physiological functions and pathological potential of neuroglia in the central nervous system that led to a notion of fundamental contribution of glial cells into multiple neuropathologies, including neuropsychiatric and developmental disorders. Growing evidence indicates a role for deregulation of astroglial control over homeostasis and plastic potential of neural networks as well as microglial malfunction and neuroinflammatory response in the brains of autistic patients. In this review, we shall summarize the status and pathological potential of neuroglia and argue for neuroglial roots of autistic disorders.
Keywords		autism gene environmental factors neurone astrocyte oligodendrocyte NG2 cells microglia