Author/Editor		Verkhratsky, Alexei; Fernyhough, Paul
Title		Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies
Type		članek
Vol. and No.		Letnik 56, št. 5
Publication year		2014
Volume		str. 262-371
ISSN		0143-4160 - Cell calcium
Language		eng
Abstract		Peripheral sensory nervous system is comprised of neurones with their axons and neuroglia that includes satellite glial cells in sensory ganglia, myelinating, non-myelinating and perisynaptic Schwann cells. Pathogenesis of peripheral diabetic polyneuropathies is associated with aberrant function of both neurones and glia. Deregulated Ca(2+) homoeostasis and aberrant Ca(2+) signalling in neuronal and glial elements contributes to many forms of neuropathology and is fundamental to neurodegenerative diseases. In diabetes both neurones and glia experience metabolic stress and mitochondrial dysfunction which lead to deregulation of Ca(2+) homeostasis and Ca(2+) signalling, which in their turn lead to pathological cellular reactions contributing to development of diabetic neuropathies. Molecular cascades responsible for Ca(2+) homeostasis and signalling, therefore, can be regarded as potential therapeutic targets.
Keywords		diabetes diabetic neuropathies insulin sladkorna bolezen diabetična nevropatija inzulin