Author/Editor		Rose, Christopher F.; Verkhratsky, Alexei; Parpura, Vladimir
Title		Astrocyte glutamine synthetase
Type		članek
Source		In: Biochemical Society Focused Meeting: CRISPR Evolution, Mechanisms and Infection, Biochemical Society/European Society for Neurochemistry Focused Meeting 5th Conference on Advances in Molecular Mechanisms Underlying Neurological Disorders,Independent Meeting The 7th International Fission Yeast Meeting : selected oral communications London : Portland Press : Biochemical Society
Publication year		2013
Volume		str. 1518-1524
Language		eng
Abstract		The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and neurotransmitter homoeostasis. GS (glutamine synthetase), which catalyses the ATP-dependent condensation of ammonia and glutamate to form glutamine, is an enzyme particularly found in astrocytes. GS plays a pivotal role in glutamate and glutamine homoeostasis, orchestrating astrocyte glutamate uptake/release and the glutamate%glutamine cycle. Furthermore, astrocytes bear the brunt of clearing ammoniainthebrain,preventingneurotoxicity. Thepresentreviewdepictsthecentralfunctionofastrocytes, concentrating on the importance of GS in glutamate/glutamine metabolism and ammonia detoxification in health and disease.
Keywords		brain activation of microglia nevrons možgani aktivacija mikroglije nevroni