Author/Editor     Verkhratsky, Alexei; Pankratov, Yuri; Lalo, Ulyana; Nedergaard, Maiken
Title     P2X receptors in neuroglia
Type     članek
Vol. and No.     Letnik 1, št. 2
Publication year     2012
Volume     str. 1-16
ISSN     2190-4618 - Wiley interdisciplinary reviews. Membrane transport and signaling
Language     eng
Abstract     Different types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X 1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in cytoplasmic Ca 2+ and Na + concentrations. Oligodendrocytes express several types of P2X receptors that may control their development and mediate axonal-glial interactions. In microglia, P2X 4 and P2X 7 receptors regulate numerous events associated with microglial activation, motility, and release of proinflammatory factors.
Keywords     astrocytes
neuroglia
P2X receptors
astrociti
nevroglija
P2X receptorji