Author/Editor | Verkhratsky, Alexei; Pankratov, Yuri; Lalo, Ulyana; Nedergaard, Maiken | |
Title | P2X receptors in neuroglia | |
Type | članek | |
Vol. and No. | Letnik 1, št. 2 | |
Publication year | 2012 | |
Volume | str. 1-16 | |
ISSN | 2190-4618 - Wiley interdisciplinary reviews. Membrane transport and signaling | |
Language | eng | |
Abstract | Different types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X 1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in cytoplasmic Ca 2+ and Na + concentrations. Oligodendrocytes express several types of P2X receptors that may control their development and mediate axonal-glial interactions. In microglia, P2X 4 and P2X 7 receptors regulate numerous events associated with microglial activation, motility, and release of proinflammatory factors. | |
Keywords | astrocytes neuroglia P2X receptors astrociti nevroglija P2X receptorji |