| Author/Editor | Guerrero-Hernandez, Austin; Dagnino-Acosta, Adan; Verkhratsky, Alexei | |
| Title | An intelligent sarco-endoplasmic reticulum Ca[sup]2+ store | |
| Type | članek | |
| Vol. and No. | Letnik 48, št. 2/3 | |
| Publication year | 2010 | |
| Volume | str. 143-149 | |
| ISSN | 0143-4160 - Cell calcium | |
| Language | eng | |
| Abstract | Simultaneous recording of cytosolic and sarco-endoplasmic reticulum (SR/ER) luminal free calcium concentrations ([Ca2+]i and [Ca2+]L, respectively) supports the notion that release channels (RyRs and IP3Rs) use a concealed Ca2+ source, likely to be associated with intra-SR/ER Ca2+ binding proteins, whereas SR/ER Ca2+ leak channels can only access free luminal Ca2+. We hypothesize that Ca2+ is trapped by oligomers of luminal Ca2+-binding proteins and that the opening of release channels induces the rapid liberation of this concealed Ca2+ source associated with intra-ER Ca2+ buffers. Our hypothesis may also clarify why SERCA pumps potentiate Ca2+ release and explain quantal characteristics and refractory states of Ca2+ release process. | |
| Keywords | endoplasmic reticulum proteins receptors endoplazemski retikulum proteini receptorji |